Synthesis, Structural Elucidation, and In Vitro Biological Activities of Novel Thiosemicarbazone Derivatives

Authors

  • Dr. Himanshu Sharma Professor Department of Chemistry Meerut Institute of Engineering & Technology Meerut Author
  • Dr. Priti Sharma Principal & Senior Lecturer in Chemistry Government Girls Inter College, Baghpat Author

Keywords:

Spectral data confirmed the successful formation of all target thiosemicarbazones. Several derivatives exhibited pronounced cytotoxic activity, with compound TSC-4 showing remarkable potency against the MCF-7 cell line (IC₅₀ = 4.2 ± 0.3 μM). Furthermore, select compounds demonstrated significant antimicrobial activity, particularly against Staphylococcus aureus. Preliminary structure-activity relationship (SAR) analysis indicated that the presence of electron-withdrawing groups and heterocyclic rings correlated with enhanced biological efficacy

Abstract

Thiosemicarbazones represent a privileged scaffold in medicinal chemistry, renowned for their versatile coordination chemistry and broad-spectrum pharmacological activities, including significant anticancer, antimicrobial, and antiviral properties. Their ability to chelate metal ions is often pivotal to their mechanism of action.

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Published

2015-01-27

Issue

Vol. 5 No. 1 (2015): January-March

Section

Articles

How to Cite

Synthesis, Structural Elucidation, and In Vitro Biological Activities of Novel Thiosemicarbazone Derivatives. (2015). INTERNATIONAL JOURNAL OF MANAGEMENT RESEARCH AND REVIEW, 5(1), 1-12. https://ijmrr.com/index.php/ijmrr/article/view/211

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